Fundamentals of Immunology Quiz

Coursera Fundamentals of Immunology Quiz: Death by Friendly Fire | Week (1-4)

Coursera Fundamentals of Immunology Quiz: Death by Friendly Fire | Week (1-4)

 
Fundamentals of Immunology: Death by Friendly Fire Quiz | Week (1-4)

 

 

Fundamentals of Immunology: Death by Friendly Fire

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Instructor: Alma Moon Novotny, Ph.D.

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Week- 1
Quiz 1

 
 
 
 
Question 1
1. Both __________ cells have αβ receptors.
  • NK; NKT
  • NKT; Treg
  • Tc; B
  • B; γδ
  • γδ; TH
  • TH; NK
 
Question 2
2. Both ___________ cells and fully adaptive, rearranging their receptor genes randomly and producing a vast number of different receptors.
 
  • NK; NKT
  • NKT; Treg
  • Tc; B
  • B; γδ
  • γδ; TH
  • TH; NK
 
Question 3
3. Macrophages and NK cells both have ________ receptors.
 
  • CD8 co-
  • CD3 co-
  • αβ TCR
  • γδ TCR
  • antibody (Fc)
  • inhibitory MHC I
 
 
Question 4
4. ______ have inhibitory MHC I receptors.
 
  • Only NK cells
  • Only Tc cells
  • Both NK and Tc cells
  • Neither NK nor Tc cells
 
 
Question 5
5. This picture shows an NK cell interacting with a viral-infected cell. The virus has blocked display of MHC I, although it cannot prevent the cell from showing signs of stress. The NK cell ______ attack because _______.
 
  • will; without MHC I inhibition, the stress ligand will prompt attack
  • will; the cell will activate ADCC in the NK cell
  • will not; there is no MHC I to activate attack
  • will not; there are no antibodies present to prompt ADCC
 
 
Question 6
6. This picture shows a CTL interacting with a healthy cell. The CTL ______ attack because _______.
 
  • will; it can bind to the peptides displayed the MHC I
  • will; the CTL has been activated by the TH cells
  • will not; the TCR and CD8 cannot recognize this type of MHC
  • will not; negative selection has removed any Tc cells that can recognize the antigen
 
 
Question 7
7. This picture shows a CTL cell infected with a virus capable of substituting its own fake MHC for the cell’s. The CTL ____ attack because _____.
 
  • will not; the TCR and CD8 cannot recognize this type of MHC
  • will not; negative selection has removed any Tc cells that can recognize the antigen
  • will; it can bind to the peptides displayed the MHC I
  • will; a CTL has been activated by the TH cells
 
 
Question 8
8. This drawing represents an NK cell from a mouse with a mutation that allows the MHC receptor to distinguish between native MHC and viral analogs. This cell _______ attack viral-infected cells displaying such analogs because these analogs _______.
 
  • will; display viral peptides
  • will; will not inhibit attack
  • will not; will inhibit the response
  • will not; deflect the apoptotic attack
 
 
Question 9
9. Scientists develop a number of mutant lines of mice with defective CTLs. Which of these, although disabled, nonetheless can still kill viral-infected cells?
 
  • cells with non-functioning perforin genes and functioning FAS-ligand genes
  • cells with non-functioning FAS-ligand genes and functioning perforin genes
  • cells with non-functioning versions of both perforin and FAS-ligand genes
  • A and B, but not C, will both be able to kill viral-infected cells.
  • All of these will be able to kill viral-infected cells.
 
 
Question 10
10. The conversion of LFA integrin on CTL cells from a high avidity conformation to a low avidity conformation triggers which of the following in a TC cell?
 
  • conjugate formation
  • fusion of vesicle with perforin and enzymes
  • initiation of apoptosis
  • signaling to the TH cells
  • dissociation from the target cell
 

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