The equation LLE =-log(IC50) – cLogP describes the relationship between the value of Lipophilic Ligand Efficiency (LLE) and some compound properties. What does IC50 represent?

6.
Question 6
The equation

LLE =-log(IC50) – cLogP

describes the relationship between the value of Lipophilic Ligand Efficiency (LLE) and some compound properties.

What does IC50 represent?

1 point

The compound concentration required to kill 50% of tested animal population

 

The compound concentration which activates 50% of target in vitro

 

The compound concentration which inhibits 50% of target in vitro

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cLogP is a measure of compound lipophilicity. What compound property does P represent?