Week 2 Fundamentals of Immunology Quiz Death by Friendly Fire

Week 2 Fundamentals of Immunology Quiz Death by Friendly Fire

Quiz 2

 

 

Question 1
1. PAMPs and DAMPs differ in that the ________.
  • PAMPs are derived directly from pathogens and the DAMPs from damaged self-tissue

     

  • PAMPs trigger the activation of IL-1, DAMPs do not.

     

  • PAMPs increased the inflammatory response, DAMPs lower it

     

  • DAMPs activate complement, PAMPs do not

     

  • PAMPs provide a better measure of the virulence and lethality of an infection

     

Question 2
2. Inflammatory chemokines bind to ________ receptors, which then activate ________.
  • seven-span; G proteins

     

  • seven-span; apoptosis

     

  • Ig; G proteins

     

  • Ig; integrins

     

  • tumor necrosis factor; apoptosis

     

  • tumor necrosis factor; integrins

     

Question 3
3. Based on its function, where would you be most likely to see HEV?
  • as part of the blood-brain barrier

     

  • facilitating oxygen exchange in the lungs

     

  • in vessels leading to lymph nodes, promoting extravasation of T cells

     

  • in the thymus, promoting exit of γδ cells

     

  • close to inflamed tissue, directing neutrophils and B cells to the infection

     

Question 4
4. The black pointer indicates an interaction that most directly leads to _________.
  • activation of NFAT in the neutrophil

     

  • stimulation of a toll-like receptor

     

  • shape changes in the neutrophil that cause it to insert between two endothelial cells

     

  • activation of G protein in the neutrophil

     

  • the neutrophil briefly adhering to the endothelium

     

Question 5
5. Which of the following CANNOT trigger assembly of the inflammasome
  • LPS

     

  • viral and bacterial DNA

     

  • alum

     

  • β-amyloid

     

  • UV light

     

  • Any of these things may trigger assembly and thus inflammation.

     

Question 6
6. In this picture of the inflammasome, the pointer labeled ___ indicates the site that recognized the danger signal, the arrow labeled _____ indicates the region most responsible for assembly of the overall heptamer and regions labeled _____ indicates the domain that clips the inactive IL-1 precursor, activating it.
  • I, II, III

     

  • I, III, II

     

  • II, I, III

     

  • II, III, I

     

  • III, I, II

     

  • III, II, I

     

 
Question 7
7. This compound is a __________ important in producing _________.
  • lipid; clotting and clot removal

     

  • lipid; pain and endothelial permeability

     

  • peptide; clotting and clot removal

     

  • peptide; pain and endothelial permeability

     

Question 8
8. Lipoxygenases are important in the production of ________ and cyclo-oxygenases are important in producing ____________.
  • leukotrienes; prostaglandins

     

  • leukotrienes; PAF

     

  • prostaglandins; leukotrienes

     

  • prostaglandins, PAF

     

  • PAF; prostaglandins

     

  • PAF; leukotrienes

     

 
Question 9
9. The hydrolysis shown here by the yellow line is most directly triggered by the action of _______.
  • Hageman’s factor

     

  • thrombin

     

  • kallikrein

     

  • cyclo-oxygenases

     

  • GTP produce by G proteins

     

Question 10
10. Pus formation largely results from the accumulation of the remains of dead and dying ________.
  • neutrophils

     

  • macrophages

     

  • epithelial cells

     

  • sentinel dendritic cells

     

  • red blood cells and platelets