Week 2 Fundamentals of Immunology Quiz Death by Friendly Fire
1. PAMPs and DAMPs differ in that the ________.
- PAMPs are derived directly from pathogens and the DAMPs from damaged self-tissue
- PAMPs trigger the activation of IL-1, DAMPs do not.
- PAMPs increased the inflammatory response, DAMPs lower it
- DAMPs activate complement, PAMPs do not
- PAMPs provide a better measure of the virulence and lethality of an infection
2. Inflammatory chemokines bind to ________ receptors, which then activate ________.
- seven-span; G proteins
- seven-span; apoptosis
- Ig; G proteins
- Ig; integrins
- tumor necrosis factor; apoptosis
- tumor necrosis factor; integrins
3. Based on its function, where would you be most likely to see HEV?
- as part of the blood-brain barrier
- facilitating oxygen exchange in the lungs
- in vessels leading to lymph nodes, promoting extravasation of T cells
- in the thymus, promoting exit of γδ cells
- close to inflamed tissue, directing neutrophils and B cells to the infection
4. The black pointer indicates an interaction that most directly leads to _________.
- activation of NFAT in the neutrophil
- stimulation of a toll-like receptor
- shape changes in the neutrophil that cause it to insert between two endothelial cells
- activation of G protein in the neutrophil
- the neutrophil briefly adhering to the endothelium
5. Which of the following CANNOT trigger assembly of the inflammasome
- viral and bacterial DNA
- UV light
- Any of these things may trigger assembly and thus inflammation.
6. In this picture of the inflammasome, the pointer labeled ___ indicates the site that recognized the danger signal, the arrow labeled _____ indicates the region most responsible for assembly of the overall heptamer and regions labeled _____ indicates the domain that clips the inactive IL-1 precursor, activating it.
- I, II, III
- I, III, II
- II, I, III
- II, III, I
- III, I, II
- III, II, I
7. This compound is a __________ important in producing _________.
- lipid; clotting and clot removal
- lipid; pain and endothelial permeability
- peptide; clotting and clot removal
- peptide; pain and endothelial permeability
8. Lipoxygenases are important in the production of ________ and cyclo-oxygenases are important in producing ____________.
- leukotrienes; prostaglandins
- leukotrienes; PAF
- prostaglandins; leukotrienes
- prostaglandins, PAF
- PAF; prostaglandins
- PAF; leukotrienes
9. The hydrolysis shown here by the yellow line is most directly triggered by the action of _______.
- Hageman’s factor
- GTP produce by G proteins
10. Pus formation largely results from the accumulation of the remains of dead and dying ________.
- epithelial cells
- sentinel dendritic cells
- red blood cells and platelets