Week 2 Fundamentals of Immunology Quiz Death by Friendly Fire
Quiz 2
Question 1
1. PAMPs and DAMPs differ in that the ________.
-
PAMPs are derived directly from pathogens and the DAMPs from damaged self-tissue
-
PAMPs trigger the activation of IL-1, DAMPs do not.
-
PAMPs increased the inflammatory response, DAMPs lower it
-
DAMPs activate complement, PAMPs do not
-
PAMPs provide a better measure of the virulence and lethality of an infection
Question 2
2. Inflammatory chemokines bind to ________ receptors, which then activate ________.
-
seven-span; G proteins
-
seven-span; apoptosis
-
Ig; G proteins
-
Ig; integrins
-
tumor necrosis factor; apoptosis
-
tumor necrosis factor; integrins
Question 3
3. Based on its function, where would you be most likely to see HEV?
-
as part of the blood-brain barrier
-
facilitating oxygen exchange in the lungs
-
in vessels leading to lymph nodes, promoting extravasation of T cells
-
in the thymus, promoting exit of γδ cells
-
close to inflamed tissue, directing neutrophils and B cells to the infection
Question 4
4. The black pointer indicates an interaction that most directly leads to _________.
-
activation of NFAT in the neutrophil
-
stimulation of a toll-like receptor
-
shape changes in the neutrophil that cause it to insert between two endothelial cells
-
activation of G protein in the neutrophil
-
the neutrophil briefly adhering to the endothelium
Question 5
5. Which of the following CANNOT trigger assembly of the inflammasome
-
LPS
-
viral and bacterial DNA
-
alum
-
β-amyloid
-
UV light
-
Any of these things may trigger assembly and thus inflammation.
Question 6
6. In this picture of the inflammasome, the pointer labeled ___ indicates the site that recognized the danger signal, the arrow labeled _____ indicates the region most responsible for assembly of the overall heptamer and regions labeled _____ indicates the domain that clips the inactive IL-1 precursor, activating it.
-
I, II, III
-
I, III, II
-
II, I, III
-
II, III, I
-
III, I, II
-
III, II, I
Question 7
7. This compound is a __________ important in producing _________.
-
lipid; clotting and clot removal
-
lipid; pain and endothelial permeability
-
peptide; clotting and clot removal
-
peptide; pain and endothelial permeability
Question 8
8. Lipoxygenases are important in the production of ________ and cyclo-oxygenases are important in producing ____________.
-
leukotrienes; prostaglandins
-
leukotrienes; PAF
-
prostaglandins; leukotrienes
-
prostaglandins, PAF
-
PAF; prostaglandins
-
PAF; leukotrienes
Question 9
9. The hydrolysis shown here by the yellow line is most directly triggered by the action of _______.
-
Hageman’s factor
-
thrombin
-
kallikrein
-
cyclo-oxygenases
-
GTP produce by G proteins
Question 10
10. Pus formation largely results from the accumulation of the remains of dead and dying ________.
-
neutrophils
-
macrophages
-
epithelial cells
-
sentinel dendritic cells
-
red blood cells and platelets