Week 3 Coursera Fundamentals of Immunology Quiz Death by Friendly Fire
1. This molecule is activated when it _______, after which it promotes immune _______.
- is hydrolyzed by an inflammasome; tolerance
- is hydrolyzed by an inflammasome; inflammation
- releases an inhibitor; tolerance
- releases an inhibitor; inflammation
2. The rel domains of the NFκB N-terminal domain can bind to _______
- the enhancer region of pro-inflammatory genes
- IκB (the inhibitor)
- A and B
- A and C
- B and C
3. Which of the following is NOT likely to trigger a danger signal to the immune system?
- environmental toxins and irritants
- normal biomolecular components located where they shouldn’t be
- molecules normally produced only by bacteria
- breakdown products of hyaluronin and beta amyloid precursor
- protein hormones secreted by the pancreas
4. A series of events leads to the assembly of the inflammasome, some of which are listed below.
I. NLR bind danger signals.
II. Card domains of ASC and caspase bind.
III. Card domains of NLR and ASC bind.
IV. Heptamer assembles.
- I, II, III, IV
- IV, III, II, I
- I, III, II, IV
- I, III, IV, II
- III, I, IV, III
5. Generally B cells become anergic based on their interactions, or lack thereof, with T cells. Which of the following does not describe a situation where a B cell would leave the bone marrow and then essentially shut down.
- The B cell find a TH to synapse with and then the TH cell releases IL-2.
- A Treg cell synapses with it, and instructs the B cell to become anergic.
- The B cell cannot find a TH to simulate it because all the TH cells that can bind the antigen have been deleted in the thymus.
- The B cell cannot find a TH to simulate it because all the TH cells that can bind the antigen have encountered sentinel dendritic cells that did not produce B7.
6. Scientists engineer a mouse by inserting the gene for aequorin, a protein that glows green when exposed to Ca2+, into their genomes. Mouse 1 produces aequorin in the plasma, but not the bone marrow. Mouse 2 produces aequorin on the surface of most of its cells. When the scientists look for B cells that react to aequorin, they find_______.
- reactive cells in the bone marrow of both mice, and reactive cells in the plasma of mouse 1, but not 2
- reactive cells in the bone marrow of both mice, and reactive cells in the plasma of mouse 2, but not 1
- no reactive cells in the plasma of either mouse, but reactive cells in the bone marrow of mouse 1
- no reactive cells in the plasma of either mouse, but reactive cells in the bone marrow of mouse 2
7. The high concentration of CTLA 4 on the surfaces of Treg cells functions to allows the cell to ________.
- attach to presenting dendritic cells
- extravasate into secondary lymphoid organs
- recognize self antigen
- activate and undergo clonal expansion before other CD4+ cells can
- deplete the B7 in its vicinity
8. The hexokinase molecule binds ___________ as a substrate at the active site and at an allosteric site inhibiting the enzyme. The inhibitory (allosteric) site has a relatively _________ binding affinity than does the active site.
- the same compound; higher
- the same compound; lower
- different compounds; higher
- different compounds; lower
9. Mutations that block the signal indicated by the blue arrow will result in autoimmunity resulting from a failure of _________.
- Treg cell production
- negative selection due to T cell exposure to too few self-antigens
- positive selection due to inability to display either CD4 or CD8
- negative selection due to cells escaping instructions to undergo apoptosis
- T cells synthesis of the cell surface molecules necessary to extravasate into the lymph nodes
10. Fezf2 functions by ________.
- loosening the binding between histones and DNA
- inducing the differentiation of Treg cells
- binding to the enhancer regions of a wide variety of genes
- triggering an internal pathway leading to apoptosis
- inhibiting immune upregulation in the absence of danger signals